Proteomics and electron microscopic characterization of the unusual mitochondrial ribosome-related 45S complex in Leishmania tarentolae
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولIsolation and characterization of mitochondrial ribosomes and ribosomal subunits from Leishmania tarentolae.
We have analyzed Leishmania tarentolae mitochondrial ribonucleoprotein (RNP) complexes using the 9S small subunit (SSU) rRNA and the 12S large subunit (LSU) rRNA as markers, and have identified a 50S RNP particle as the putative mitochondrial monosome, a 40S particle as the putative LSU and a 30S particle as the putative SSU. These assignments are supported by morphological analysis by cryo-ele...
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A relatively thermostable 22-kDa endoribonuclease (MAR1) was purified more than 10,000-fold from a mitochondrial extract of Leishmania tarentolae and the gene cloned. The purified nuclease has a Km of 100-145 +/- 33 nM and a Vmax of 1.8-2.9 +/- 2 nmol/min, depending on the RNA substrate, and yields a 3'-OH and a 5'-phosphate. Cleavage was limited to several specific sites in the substrate RNAs ...
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a Department of Molecular, Cell and De6elopmental Biology, Howard Hughes Medical Institute, UCLA School of Medicine, UCLA, Los Angeles, CA 90095-1662, USA b Howard Hughes Medical Institute, UCLA School of Medicine, UCLA, Los Angeles, CA 90095-1662, USA c Department of Medical Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, UCLA School of Medicine, UCLA, Los Ang...
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ژورنال
عنوان ژورنال: Molecular and Biochemical Parasitology
سال: 2007
ISSN: 0166-6851
DOI: 10.1016/j.molbiopara.2007.01.012